Chemical Research
and Development Laboratory
1. Product
NORDIHYDROGUAIARETIC
ACID 99%
2. Company
KJ
Ross-Petersen ApS
Dalsgaardsvej 22
DK-2930 Klampenborg
Denmark
Phone +45
20193646
Fax +45
39179747
VAT
No. DK1151 5975
e-mail karl@ross.dk www.ross.dk
3. Composition/Information on Ingredients
Product
Name
NORDIHYDROGUAIARETIC
ACID
Synonym NDGA
CAS
No 500-38-9
EC
No. 207-903-0
Formula C18H22O4
Molecular
Weight 302.37
Percentage 100%
4. Hazards Identification
SPECIAL
INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if
swallowed. Irritating to eyes, respiratory system and skin.
5. First Aid Measures
If inhaled,
remove to fresh air. If not breathing then give artificial respiration. If
breathing is difficult, give oxygen.
AFTER SKIN
CONTACT
In case of
skin contact, flush with copious amounts of water for at least 15 minutes.
Remove contaminated clothing and shoes and wash before reuse. Call a
physician.
AFTER EYE
CONTACT
In case of
contact with eyes, flush with copious amounts of water for at least 15 minutes.
Assure adequate flushing by separating the eyelids with fingers. Call a
physician.
AFTER
INGESTION
If
swallowed, wash out mouth with water provided person is conscious. Call a
physician.
6. Fire Fighting Measures
EXTINGUISHING
MEDIA
Suitable:
Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.
SPECIAL
RISKS
Specific
Hazards: Emits toxic fumes under fire conditions.
SPECIAL
PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained
breathing apparatus and protective clothing to prevent contact with skin and
eyes.
7. Accidental Release Measures
PERSONAL
PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate
area. Vacuum or sweep up material and place in disposal container. After
removal, flush the contaminated area thoroughly with water. Avoid raising
dust.
PROCEDURES
OF PERSONAL PRECAUTIONS
Wear
respirator, chemical safety goggles, rubber boots, and Latex disposable
gloves.
METHODS FOR
CLEANING UP
Sweep up,
place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area
and wash spill site after material pickup is complete.
8. Handling
and Storage
HANDLING
Directions
for Safe Handling: Do not breathe dust. Avoid contact with eyes, skin, and
clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions
of Storage: Keep tightly closed. Store in a cool dry place.
9. Exposure Controls / Personal Protection
ENGINEERING
CONTROLS
Safety
shower and eye bath. Mechanical exhaust required.
GENERAL
HYGIENE MEASURES
Wash
thoroughly after handling.
PERSONAL
PROTECTIVE EQUIPMENT
Respiratory
Protection: Government approved respirator.
Hand
Protection: Compatible chemical-resistant gloves.
Eye
Protection: Chemical safety goggles.
10. Physical
and Chemical Properties
Physical
State: Solid
Color:
Slightly
yellow
Form:
Fine
crystals
pH No data
BP/BP
Range No
data
MP/MP
Range 186-187 °C
Flash
Point No data
Flammability No
data
Autoignition
Temp No
data
Oxidizing
Properties No data
Explosive
Properties No data
Explosion
Limits No data
Vapor
Pressure No data
Partition
Coefficient No data
Viscosity No data
Vapor
Density No data
Saturated
Vapor Conc.No data
Evaporation
Rate No data
Bulk
Density No data
Decomposition
Temp. No data
Solvent
Content No data
Water
Content <1 %
Surface
Tension N/A
Conductivity N/A
Solubility
in water Insoluble
Other
solubility data Soluble in EtOH, DMF
and DMSO
11. Stability
and Reactivity
Stable.
Materials
to Avoid: Oxidizing agents.
HAZARDOUS
DECOMPOSITION PRODUCTS
Hazardous
Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS
POLYMERIZATION
Hazardous
Polymerization: Will not occur
12. Toxicological
Information
RTECS
NUMBER: UX1750000
ACUTE
TOXICITY
LD50
Oral Rat 2000
mg/kg
LD50 Oral Mouse 2000
mg/kg
LD50 Intraperitoneal Mouse 550 mg/kg
LD50 Oral Guinea
pig 830
mg/kg
SIGNS AND
SYMPTOMS OF EXPOSURE
The
chemical, physical, and toxicological properties of this product have not been
thoroughly investigated.
ROUTE OF
EXPOSURE
Skin
Contact: Causes skin irritation.
Skin
Absorption: May be harmful if absorbed
through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material is
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
CHRONIC
EXPOSURE - MUTAGEN
Human 13500
nmol/l
Cell
Type: lymphocyte
Other
mutation test systems
Human 3600
nmol/l
Cell
Type: lymphocyte
Sister
chromatid exchange
Mouse 70700
ug/kg
Intraperitoneal
Other
mutation test systems
Mouse 35300
ug/kg
Intraperitoneal
Sister
chromatid exchange
13. Ecological
Information
No
data available.
14. Disposal
Considerations
SUBSTANCE
DISPOSAL
Contact a
licensed professional waste disposal service to dispose of this material.
Dissolve or mix the material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber. Observe all federal,
state, and local environmental regulations.
15. Transport
Information
RID/ADR
Non-hazardous
for road transport.
IMDG
Non-hazardous
for sea transport.
IATA
Non-hazardous
for air transport.
16. Regulatory
Information
CLASSIFICATION
AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION
OF DANGER: Xn
Harmful.
R-PHRASES: 22 36/37/38
Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
S-PHRASES: 26 36/37
In case of
contact with eyes, rinse immediately with plenty of water and seek medical
advice. Wear suitable protective clothing and gloves.
SWITZERLAND
SWISS POISON
CLASS: 4
17. Other
Information
WARRANTY
The above
information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide.
KJ
Ross-Petersen ApS shall not be held liable for any damage resulting from
handling or from contact with the above product.
DISCLAIMER
For R&D
use only. Not for drug, household or other uses.
Laboratory: Fruebjergvej 3 DK-2100 Copenhagen O