KJ ROSS-PETERSEN ApS

Chemical Research and Development Laboratory

 

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Material Safety Data Sheet

 

Version 1.0 July 25, 2006

 

1. Product

NORDIHYDROGUAIARETIC ACID 99%

 

2. Company

KJ Ross-Petersen ApS

Dalsgaardsvej 22

DK-2930 Klampenborg

Denmark

Phone +45 20193646

Fax +45 39179747

VAT No. DK1151 5975

e-mail karl@ross.dk www.ross.dk

 

3. Composition/Information on Ingredients

Product Name

NORDIHYDROGUAIARETIC ACID

Synonym NDGA

CAS No 500-38-9

EC No. 207-903-0

Formula C18H22O4

Molecular Weight 302.37

Percentage 100%

 

4. Hazards Identification

SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT

Harmful if swallowed. Irritating to eyes, respiratory system and skin.

 

5. First Aid Measures

AFTER INHALATION

If inhaled, remove to fresh air. If not breathing then give artificial respiration. If breathing is difficult, give oxygen.

 

AFTER SKIN CONTACT

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes and wash before reuse. Call a physician.

 

AFTER EYE CONTACT

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

 

AFTER INGESTION

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

 

6. Fire Fighting Measures

EXTINGUISHING MEDIA

Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.

 

SPECIAL RISKS

Specific Hazards: Emits toxic fumes under fire conditions.

 

SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS

Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

 

7. Accidental Release Measures

PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL

Evacuate area. Vacuum or sweep up material and place in disposal container. After removal, flush the contaminated area thoroughly with water. Avoid raising dust.

 

PROCEDURES OF PERSONAL PRECAUTIONS

Wear respirator, chemical safety goggles, rubber boots, and Latex disposable gloves.

 

METHODS FOR CLEANING UP

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

 

8. Handling and Storage

HANDLING

Directions for Safe Handling: Do not breathe dust. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure.

STORAGE

Conditions of Storage: Keep tightly closed. Store in a cool dry place.

 

9. Exposure Controls / Personal Protection

ENGINEERING CONTROLS

Safety shower and eye bath. Mechanical exhaust required.

 

GENERAL HYGIENE MEASURES

Wash thoroughly after handling.

 

PERSONAL PROTECTIVE EQUIPMENT

Respiratory Protection: Government approved respirator.

Hand Protection: Compatible chemical-resistant gloves.

Eye Protection: Chemical safety goggles.

 

10. Physical and Chemical Properties

Appearance

Physical State: Solid

Color: Slightly yellow

Form: Fine crystals

pH No data

BP/BP Range No data

MP/MP Range 186-187 C

Flash Point No data

Flammability No data

Autoignition Temp No data

Oxidizing Properties No data

Explosive Properties No data

Explosion Limits No data

Vapor Pressure No data

Partition Coefficient No data

Viscosity No data

Vapor Density No data

Saturated Vapor Conc.No data

Evaporation Rate No data

Bulk Density No data

Decomposition Temp. No data

Solvent Content No data

Water Content <1 %

Surface Tension N/A

Conductivity N/A

Solubility in water Insoluble

Other solubility data Soluble in EtOH, DMF and DMSO

 

11. Stability and Reactivity

STABILITY

Stable.

Materials to Avoid: Oxidizing agents.

 

HAZARDOUS DECOMPOSITION PRODUCTS

Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.

 

HAZARDOUS POLYMERIZATION

Hazardous Polymerization: Will not occur

 

12. Toxicological Information

RTECS NUMBER: UX1750000

ACUTE TOXICITY

LD50 Oral Rat 2000 mg/kg

LD50 Oral Mouse 2000 mg/kg

LD50 Intraperitoneal Mouse 550 mg/kg

LD50 Oral Guinea pig 830 mg/kg

 

SIGNS AND SYMPTOMS OF EXPOSURE

The chemical, physical, and toxicological properties of this product have not been thoroughly investigated.

 

ROUTE OF EXPOSURE

Skin Contact: Causes skin irritation.

Skin Absorption: May be harmful if absorbed through the skin.

Eye Contact: Causes eye irritation.

Inhalation: May be harmful if inhaled. Material is irritating to mucous membranes and upper respiratory tract.

Ingestion: Harmful if swallowed.

 

CHRONIC EXPOSURE - MUTAGEN

Human 13500 nmol/l

Cell Type: lymphocyte

Other mutation test systems

Human 3600 nmol/l

Cell Type: lymphocyte

Sister chromatid exchange

Mouse 70700 ug/kg

Intraperitoneal

Other mutation test systems

Mouse 35300 ug/kg

Intraperitoneal

Sister chromatid exchange

 

13. Ecological Information

No data available.

 

14. Disposal Considerations

SUBSTANCE DISPOSAL

Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations.

 

15. Transport Information

RID/ADR

Non-hazardous for road transport.

IMDG

Non-hazardous for sea transport.

IATA

Non-hazardous for air transport.

 

16. Regulatory Information

CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES

 

INDICATION OF DANGER: Xn

Harmful.

 

R-PHRASES: 22 36/37/38

Harmful if swallowed. Irritating to eyes, respiratory system and skin.

 

S-PHRASES: 26 36/37

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

 

SWITZERLAND

SWISS POISON CLASS: 4

 

17. Other Information

WARRANTY

The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide.

KJ Ross-Petersen ApS shall not be held liable for any damage resulting from handling or from contact with the above product.

 

DISCLAIMER

For R&D use only. Not for drug, household or other uses.

 

 

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Office: Dalsgaardsvej 22 DK-2930 Klampenborg Denmark www.ross.dk

Laboratory: Fruebjergvej 3 DK-2100 Copenhagen O